Tamoxifen   -   Antineoplastic  /  Antioestrogen

  
Exporters / Distributors of Tamoxifen Citrate tablets, an antineoplastic - antioestrogen drug, used in the treatment of advanced or metastatic carcinoma of breast

  

 Action :

Anonsteroidal potent antioestrogen. It competes with oestradiol for oestrogen receptor protein in target tissues. Actions are similar to clomiphene.

  

 Indication :

Palliative treatment of advanced or metastatic carcinoma of breast.

  

 Pharmaco-Kinetics :

It is given orally, the drug has biphasic half life.

  

 Contraindication :

Hypersensitvity.

  

 Adverse-Effects :

Nausea, vomiting, hot flushes, vaginal bleeding, dermatitis, pruritus vulvae, menstrual irregularities.

  

 Special Precaution :

Premenopausal women.

  

 Interactions :

Oral anticoagulants

:

Significant increase in anticoagulant effect requiring careful monitoring of prothrombin time.

Bromocriptine

:

Serum tamoxifen levels are elevated.

Cyclophosphamide

:

Since tamoxifen is a potent inhibitor of cytochrome P450 oxidase it may affect metabolism and excretion of cyclophosphamide.

  

 Dosage :

10-20mg twice daily (morning & evening).

  

 Duration of action :

Terminal half-life > 24 hours.

  

 Strength & Packing :

10mg tablet, 
20mg tablet,  10 tablets per box.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.