Pancuronium  Bromide  -  Non-depolarising muscle relaxant

  

 Action :

A non-depolarising neuromuscular blocking agent with curarimimetic action. Competetive blockade at myoneural junction. During anaesthesia (halothane) there is a rise in heart rate, mean arterial pressure and cardiac output.

  

 Indication :

Medium acting nondepolarising muscle relaxation in surgical anaesthesia, assisted ventilation.

    

 Pharmaco-Kinetics :

It has little effect on the circulatory system, except for a moderate rise in heart rate, mean arterial pressure and cardiac output.  About 87%  is bound  to plasma protein.  Elimination half life is doubled in hepatic impairment and renal failure.

    

 Contraindication :

Hypersensitivity.

  

 Adverse-Effects :

Transient fall in blood pressure, reduction in GI  motility and tone, wheal-and-flare effects at site of injection.

  

 Special Precaution :

Myasthenia gravis, renal, hepatic and pulmonary function impairment, billiary tract disease, severe obesity.

  

 Interactions :

Antibiotics

:

Parenteral doses of these antibiotics used pre-operatively may produce unexpected prolongation of neuromuscular blockade.

Azathioprine

:

Causes reversal of neuromuscular blocking effect of pancuronium.

Inhalation anaesthetics

:

Potentiation of neuromuscular blockade.

Magnesium Sulphate

:

Neuromuscular blockade of pancuronium enhanced.

Other neuromuscular blocking agents

:

Synergistic effect though the blockade is not prolonged.
Quininen : Effects of pancuronium enhanced.
Succinylcholine : Prior administration enhances the relaxant effects of pancuronium and its duration of action.
Theophylline : The effect of pancuronium may be reversed. Chances of cardiac arryhthmias.

  

 Dosage :

Adults : 
Initial dose  :  40 - 100 mcg / kg body weight by I.V. route. 
followed by : 10 - 20 mcg / kg body weight. 

  

 Duration of action :

1 hour.

    

 Strength & Packing :

 

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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