It acts by relaxation of vascular smooth muscle; consequently it dilates peripheral arteries and veins. It is more active on veins than on arteries. It reduces both preload & afterload which will reduce workload on the heart. In hypertensive patients, moderate doses induce renal vasodilation roughly proportional to the decrease in systemic blood pressure; thus there is no appreciable change in RBF and GFR. Hypotensive effect is seen within a minute or two after the start of an adequate infusion, and it dissipates almost as rapidly after infusion is discontinued.

Hypertensive crisis, Congenstive heart failure, Controlled hypotension, acute mitral regurgination.

It is given parenterally and onset of action occurs quickly (within 1 minute). On stopping I.V. infusion, the effect dissipates rapidly.

Compensatory hypertension.

None except in overdosage. Nausea, retching, apprehension, headache, restlessness, muscle twitching, dizziness.

Sodium nitroprusside decomposes on exposure to light, so the container must be protected from light.

Adults : 
Hypertensive crisis :  in patients not already receiving antihypertensives, by i.v. infussion 0.3-1mcg / kg / minute initially, then adjusted; lover doses for patients already being reated with antihyper-tensives.

Heart failure :  by i.v. infusion initially 10-15mcg / kg/ minute, increase every 5-10 minutes as necessary, usual range 10-200mcg / kg / minute.

  
Children :
Begin with infusion rate of 0.003 mg / kg / minute and decrease or increase dosage according to response. Only 5% Dextrose in water to be used. No other drug in IV solution. 

3 - 5 minutes. 

50mg / ml,  5ml  vial.  

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

[Go Back to the Export product list]

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.