Action on the reproductive cell cycle is not highly phase-specific. However, effect is more prominent on proliferating cells in S-phase. Cytotoxic action is partly due to damage to DNA. Mustine also has weak immunosuppressant property.

Malignancies of the lung, certain types of chronic leukaemia, palliation of Hodgkin's disease. Neuroblastoma, mycosis fungoides.

It is administered by parenteral route (I.V.)

Severe leucopenia, thrombocytopenia, anaemia, drug is not to be repeated before 6 weeks. Coexisting or suspected granuloma.

Nausea, vomiting, diarrhoea, leucopenia bone marrow depression, skin rash, alopecia, transient anorexia, amenorrhoea, sterility, oral ulcers. Local reaction & phlebitis.

Extravasation into subcutaneous tissues, monitor renal, hepatic and bone marrow functions. Concomitant therapy with x-ray or other chemotherapy. Immunosuppressive activity may predispose to infection.

Adults : Normally 0.1mg / kg body weight daily for 3-4 days. No single dose should exceed 8mg regardless of body weight, infused with 500ml of normal saline. 
Not for I.M. use.

Within few mins.

Injection.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

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