Mitomycin C   -   Antineoplastic  Antibiotic

  
Manufacturers / Exporters of Mitomycin 'C' injection, an anti-neoplastic antibiotic drug, used in the treatment of bladder cancer

  

 Action :

Converted to an active metabolite. Inhibits DNA synthesis as also that of RNA and protein. May be selectively toxic to hypoxic cells because it may generate superoxide and hydroxylradicals. Effects are most marked in the late G1 and early S phases of cell cycle.

  

 Indication :

Ademocarcinoma, lymphosarcoma and seminoma. Superficial bladder cancer as a adjuvant in primary or recurrent pterygia.

  

 Pharmaco-Kinetics :

After oral administration it exhibits inconsistent absorption. Hence it is administered by intravenous route. It is metabolised in liver.

  

 Contraindication :

Haemorrhagic tendencies, bone marrow depression, not to be given I.M. or S.C., thrombocytopenia.

  

 Adverse-Effects :

Nausea, vomiting, allergic reactions, fever, alopecia, pulmonary fibrosis, bone marrow depression, renal toxicity, sterility, stomatitis, amenorrhoea.

  

 Special Precaution :

Leucopenia, mouth ulcers. Monitor renal function and haematological status.

  

 Interactions :

Vinva alkaloids

:

Acute shortness of breath and severe bronchospasm have occurred following the use of vinca alkaloids in patients who had previously or concurrently received mitomycin.

  

 Dosage :

Adults

:

6-10mg I.V. twice weekly or 0.05mg / kg body weight daily for 5 days repeating schedule after 2 days to a total dose of 60-100mg.

   

 Duration of action :

Terminal elimination half-life 50 mins.

    

 Strength & Packing :

  2mg  Injection,  
10mg  Injection,  single vial per box.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.