Hydroxyurea   -   Cytotoxic  Antineoplastic

  
Manufacturers of Hydroxyurea 500mg capsules, a Oncology medicine, used for the treatment of leukaemia, and in combination with radiotherapy in carcinoma of cervix, head, neck and lung

  

 Action :

Causes cell death by specific inhibition of DNA synthesis. This action causes regressions in chronic myeloid leukemia and other malignancies and psoriasis. The S-phase-specific action of hydroxyurea can deplete bone marrow precursor cells associated with megaloblastic changes.

  

 Indication :

In treatment of myeloproliferative disorders including chronic granulocytic leukaemia, polycythemia vera and essential thrombocytosis. Melanoma, metastatic or inoperable carcinoma of ovary. In combination with radiotherapy in carcinoma of cervix, head, neck and lung.

  

 Pharmaco-Kinetics :

After oral administration it is readily absorbed from GI tract. Hydroxyurea readily crosses blood brain barrier.

  

 Contraindication :

Severe anaemia, marked bone marrow depression.

  

 Adverse-Effects :

Nausea, vomiting, rash, bone marrow depression is the major toxic effect. Alopecia, stomatitis, dysuria. Inflamation and increased pigmentation may occur in areas exposed to radiation. Rare neurological disturbances.

  

 Special Precaution :

Monitor hepatic and renal functions. Haematological monitoring (including bone marrow). Premenopausal women, recent x-ray or cytotoxic therapy.

  

 Interactions :

Lab tests : May cause increase in serum uric acid, creatinine and BUN levels.

  

 Dosage :

Adults

:

Solid tumours

:

Intermittent therapy : 80mg/kg as single dose every 3rd day.
Continuous therapy : 20-30mg/kg as single daily dose.

Carcinoma of head and neck

:

80mg/kg as a single dose every 3rd day. Begin therapy atleast 7 days before initiation of irradiation therapy.

Resistant chronic myelocytic leukaemia

 :

Continuous therapy of 20-30mg/kg as a single daily dose is recommended.

Children

:

Dosage regimens have not been established.

  

 Onset of action :

Dosage regimens have not been established.  

    

 Strength & Packing :

500mg capsule,  20 capsules per box (10 caps x 2 strips).

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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