Cytarabine  (Cytosinearabinoside)  -   Antineoplastic

  
Manufacturers of Cytarabine injection, an anti cancer / oncology drug, used in the treatment of cancer, acute myelocytic, lymphocytic leukaemia

  

 Action :

Cytarabine is cytotoxic to a wide variety of actively dividing mammalian cells. It acts by interfering with pyrimidine synthesis. It is a potent myelosuppressant and requires careful haematological monitoring during its use.

  

 Indication :

Acute myelocytic leukaemia, acute lymphocytic leukaemia, chronic myeloid leukaemia (blast phase), non-Hodgkin's lymphoma in children, treatment and maintenance of meningeal neoplasms, erythroleukaemia.

  

 Adverse-Effects :

Leucopenia, anaemia, thrombocytopenia, reticulocytopenia, GI disturbances, oral and anal ulceration. Hepatic, renal dysfunction, thrombophlebitis, central and peripheral neurotoxicity with high doses, rhabdomyolysis, conjunctivitis, anaphylaxis.

  

 Special Precaution :

To monitor drug tolerance, haematological, hepatic function, uric acid level monitoring. Women of childbearing age. Use in infants. Intrathecal use.

  

 Interactions :

Radiotherapy & Other myelotoxic drugs

:

Done marrow depression potentiated.
Digoxin : Decreased serum levels of digoxin. Effect seen even several days after stopping therapy.

Gentamicin & Flurocytosine

:

Efficacy of both decreased.

  

 Dosage :

Adults : 100mg/m2 I.V. every 12 hours for 7 days. 

  

 Onset of action :

Within mins.  

  

 Duration of action :

Terminal elimination half-life 1 - 3 hours.

    

 Strength & Packing :

100mg / 5ml  Injection,  
500mg / 5ml  Injection,  10 ampoules per box.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.