Cisplatinum   -   Antineoplastic platinum compound

  
Manufacturers of Cisplatin injection, an anti-neoplastic platinum compound

  

 Action :

Modifies cell cycle by interfering with DNA structure and function. Effects are most prominent during the S phase but cells are killed at all stages. Cisplatin synergises with other anticancer drugs such as fluorouracil. Cisplatin has a narrow therapeutic margin and has high toxicity.

  

 Indication :

Metastatic testicular and ovarian carcinoma, advanced bladder cancers, refractory squamous cell neck and head carcinomas.

  

 Pharmaco-Kinetics :

It is not effective after oral administration. It is given by intravenous route.

  

 Contraindication :

Renal impairment. Platinum hypersensitivity, hearing disorders.

  

 Adverse-Effects :

Nausea, vomiting, fever, anaphylactic reactions, hypokalaemia, hypomagnesaemia, haemolysis, renal damage, sterility, teratogenesis, ototoxicity, peripheral neuropathy, raynaud's disease, bone marrow depression.

  

 Special Precaution :

Hypocalcaemia, hypomagnesaemia, monitor neurological status, renal status and haematological function. Maintain hydration. 

  

 Interactions :

Aminoglycosides

:

Nephrotoxicity potentiated by aminoglycosides.

Loop diuretics

:

Additive ototoxic effect.

Phenytoin

:

Plasma levels reduced by cisplatin.

Cytotoxic drugs

:

Increased toxicity when combined with other cytotoxic drugs. Still ideal drug to combine since it causes very little myelosuppression.

5-Fluorouracil & Etoposide

:

Synergy.

Radioprotecting Agent WR 2721

:

Efficacy enhanced and toxicity reduced.

  

 Dosage :

Testicular tumors

:

20mg / m2 / day I.V. for 5 days (day 1-5) every 3 weeks, for 3 courses.

Ovarian tumor

:

50mg / m2  I.V. once every 3 - 4 weeks.

Note

:

Do not use needles &  I.V. sets containing aluminum components.

  

 Duration of action :

Initial half-life 25 - 49 mins, terminal elimination half-life 58 - 73 hours.

  

 Strength & Packing :

10mg / 20ml  Injection, 
50mg / 50ml  Injection.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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