Vincristine  Sulphate   -   Antineoplastic

  
Manufacturers of Vincristine Sulphate injection, an anti neoplastic drug, used in the treatment of acute leukaemias, wilms tumor

  

 Action :

Vincristine arrests cell division at the metaphase stage by inhibiting microtubule formation in the mitotic spindle.

  

 Indication :

Acute leukaemias, lymphomas & certain other malignant conditions, neuroblastoma, wilms tumor other : idiopathic thrombocytopenic purpura.

  

 Pharmaco-Kinetics :

After oral administration the absorption is unpredictable. It is metabolised in liver.

  

 Contraindication :

Intrathecal administration, demyelinating charcot marie tooth syndrome.

  

 Adverse-Effects :

Local reaction if extravasation occurs, constipation, paralytic ileus, jaw pain, alopecia, bone marrow depression, peripheral neuropathy. Inappropriate ADH secretion. Shortness of breath, bronchospasm, hypo or hypertension.

  

 Special Precaution :

Infection, neuromuscular disease, leucopenia, pulmonary disorders, leukaemia, radiation therapy, extravasation, concomitant neurotoxic drugs. Eye contact, concurrent vaccination.

  

 Interactions :

Digoxin

:

Decreased plasma digoxin levels and renal excretion.

L-asparginase

:

Hepatic clearance of vincristine is reduced if L-Asparginase is administered first. Thus to minimize toxicity, vincristine should be given 12 to 24 hours before administering L-asparginase.

Mitomycin C

:

Acute pulmonary reaction may occur.

Phenytoin

:

Reduced phenytoin plasma levels.

  

 Dosage :

Adults

:

1.4mg / sq. m. body surface / weekly.

Children

:

   2mg / sq. m. body surface / weekly.

  

 Onset of action :

15 - 30 mins. following I.V. administration.

  

 Duration of action :

19 - 155 hours.

  

 Strength & Packing :

1mg Injection, 
5mg Injection,  single vial per box.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.