Thiopental Sodium  -  Ultra-short-acting barbiturate.

  

 Action :

CNS depressant inducing hypnosis and anaesthesia but not analgesia. Action sets in within 30-40 seconds of IV injection. Recovery is quick but repeated doses may prolong anaesthesia. The drug is stored in fatty tissue and released gradually.

  

 Indication :

Anaesthesia of short duration, status epilepticus.  Rapid control of convulsions. Infusion of subanaesthetic doses can be used to facilitate verbal communication with psychiatric patients.

    

 Pharmaco-Kinetics :

After  administration it is distributed  initially in organs which are highly vascular e.g. Brain.  Subsequently the termination of its effect depends upon depends upon redistribution of drug from brain to fatty tissues and other tissues.

    

 Contraindication :

Hypersensitivity, hypo tension, status asthamaticus, hepatic dysfunction, Addision’s disease, myxoedema, acute intermittent porphyria and severe cardiovascular disease.

  

 Adverse-Effects :

Hypo tension, hiccups, apnoea for short period, nausea, vomiting.

  

 Special Precaution :

Thiopentone should  not be mixed with succinylcholine in the same syringe.

  

 Interactions :

Narcotics

:

Those of phenobarbitone required to induce anaesthesia reduced.

Phenothiazines

:

Increased frequency and severity of neuromuscular excitation and hypotension.

  

 Dosage :

Adults : 

Inject I.V. (3 - 5 mg / kg) as a 2.5 mg soln.  
It produces unconsciousness in 15 - 30 sec.

  

 Duration of action :

20 - 30 mins.

    

 Strength & Packing :

 

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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