Succinyl Choline Chloride  - Depolarizing muscle relaxant

  
Manufacturers of Succinyl Choline Chloride, Suxamethonium Chloride injection, a depolarizing muscle relaxant, an Anaesthetic drug

  

 Action :

An ultrashort acting depolarising type skeletal muscle relaxant, Blocks the neuromuscular junction by combining with the cholinergic receptors and depolarising them. Onset of flaccid paralysis is rapid (less than 1 min) and lasts for about 4-6 min after IV administration. No action on smooth muscle or uterus. No effect on consciousness, pain.

  

 Indication :

Tracheal incubation, short operations, orthopedic, manipulation, electro convulsive therapy and closure of the peritoneum. Prolonged muscular relaxation in surgery can be attained by means of repeated injections of the drug by continuous intravenous drip.

    

 Pharmaco-Kinetics :

After administration it is rapidly hydrolysed by butyrylcholine esterase of liver and plasma. Patient who show prolonged apnoea after succinylcholine administration have atypical plasma cholinesterase or deficiency of enzyme due to genetic factor.

    

 Contraindication :

History of malignant hyperthermia, renal failure, severe burns, glaucoma, open eye injury, congenital myotonic disease, inadequate general anaesthesia, after major trauma, neurological disorders associated with muscle wasting.

  

 Adverse-Effects :

Hyperkalaemia-related cardiac arrest, muscle pain. Respiratory depression or apnoea, malignant hyperthermia, excessive salivation, myoglobinuria, rise in intraocular pressure, tachycardia or bradycardia. Serious histamine mediated flushing, broncho-constriction and hypotension are uncommom in normal clinical usage.

  

 Special Precaution :

Renal or hepatic failure, myasthenia gravis. Repeated injection can cause bradycardia, extra-systoles, other cardiac irregularities.

  

 Interactions :

Diazepam

:

Reduces duration of neuromuscular blockade produced by succinylcholine chloride.

Phenelzine, Promazine, Oxytocin, certain Non-penicillin antibiotics, Quinidine, Betablockers, Procainamide, Lidocaine, Trimethaphan, Lithium carbonate, Furosemide, Magnesium sulphate, Quinin, Chloroquine, Acetylcholine, Anticholinesterases, Procaine, type local anaesthetics and isoflurance : May enhance the efficacy of succinylcholine.

Amphotericin B and Thiazide diuretics

:

Electrolyte imbalances caused by these result in increased effects of succinylcholine.

Cyclophosphamide, IV Procaine

:

Prolong the effects of succinylcholine.

Digitals glycosides

:

Toxicity of both drugs may be increased.

Inhalation anaesthetics (e.g. cyclopropane,diethylether halothane and nitrous oxide) : Increased incidence of bradycardia, arrhythmias, sinus arrest and apnoea. Malignant hyperthermia may occur in susceptible individuals.

Narcotic analgesics

:

Increased incidence of bradycardia and cardiac arrest.

  

 Dosage :

Adults : 20mg (0.4ml) to 100mg (2ml).

Intubation : 50mg (1ml) to 80mg (1.6ml)

For administration by continuous I.V. drip. a 0.1% soln may be prepared by mixing 10ml injection of succinylcholine with 500ml of 5% glucose or isotonic sodium chloride. The adult dose ranges from 2 to 5mg per minute.

  

 Duration of action :

1 - 5 minutes.

    

 Strength & Packing :

 

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.