Streptokinase  -  Thrombolytic / Plasminogen Activator

  
Exporters / Distributors of Streptokinase injection, a thrombolytic / plasminogen activator, used in acute myocardial infarction

  

 Action :

Forms a complex with plasminogen which then converts plasminogen to plasmin. Plasmin breaks down clots as well as fibrinogen and other plasma proteins.

  

 Indication :

Acute myocardial infarction. Pulmonary embolism. Deep Vein thrombosis. Arterial thrombosis. Acute thrombosis of central retinal vessels, extensive coronary emboli, severe ileofemoral thrombophlebitis.

 

 Pharmaco-Kinetics :

It is given by parental route and has a short plasma half life.

    

 Contraindication :

Surgery within 10 days, severe hypertension, serious gastrointestinal bleeding, haemorrhagic disorder, previous cerebrovascular accident.

  

 Adverse-Effects :

Fever, allergic reactions, bleeding from different sites, rarely anaphylaxis, arrhythmias, bronchospasm.

  

 Special Precaution :

Sub-acute bacterial endocarditic parturition, kidney or liver impairment.

  

 Interactions :

Anticoagulants and antiplatelet agents

:

May cause bleeding complications. Therefore patients should be carefully monitored.

Lab Tests

:

 Marked decrease in plasminogen and fibrinogen. Increase in thrombin time (TT), activated partial thromboplastin time (APTT), & prothrombin time (PT).

   

 Dosage :

Adults : 
Acute myocardial onfarction :  I.V.  750,000 - 15 million I.U. in 1 hour. 
Intracoronary : 20,000 I.U. stat followed by 2000 - 4000 I.U./ min. for 30 - 90 min. 

  

 Duration of action :

Hyper-fibrinolytic effect lasts for few hours. 

    

 Strength & Packing :

1,500,000 I.U.,  single vial pack.
  

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.