Pralidoxime Chloride -  Antidote (Cholinesterare Reactivator)

  

 Action :

Reactivates cholinesterase outside the CNS which has been inactivated by organophosphate pesticides and related compounds.  This leads to destruction of the excessive acetylcholine blocking the neuromuscular function.  The latter starts functioning again.  Pralidoxime is effective in relieving paralysis of respiratory muscles.  It is usually given in conjunction with atropine to treat OP poisoning.

   

 Indication :

Antidotes for  organophosphorus poisoning like malathion, TEPP, parathion, dichlorvos, fenthion. 

   

 Pharmaco-Kinetics :

After administration it is metabolised in liver.

    

 Contraindication :

 

  

 Adverse-Effects :

Blurred vision, dizziness, diplopia, headache tachycardia, mild weakness and nausea.  In high dose it can cause neuromuscular blockade.

  

 Special Precaution :

It should be administered after Atropine injection, Myasthenia Gravis.

  

 Interactions :

Barbiturates : Use with caution in treatment of convulsions because barbiturates are potentiated by anticholinerases.

Morphine, Theophilline, Aminophylline, Succinylcholine, Reserpine and Phenothiazines : Avoid in patients with organophosphorus poisoning.

   

 Dosage :

Adults : 
Inj. : Following resuscitation measures, and 2 - 4mg Atrophine inj., 
1 - 2g I.M. or  
I.V. as 5% solution. over 5 - 10 min. or 
Infusion in 100ml sod. chl. over 15 - 30 min. 
Repeat theraphy if required.

  

 Duration of action :

1 - 3 hours.

    

 Strength & Packing :

500mg vial,  (2 vials + 2 amps 20ml water for injection).
500mg tablets,  (50 tablets per box)  

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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