Paclitaxel   -   Antitumor activity

  

 Action :

It binds specifically to B-tubulin subunit of microtubule and appears to antagonise the disassembly of this cyto-skeletal protein. Arrest in mitosis follows. The cell killing is dependent on both drug concentration and duration of cell exposure.

  

 Indication :

Metastatic ovarian and breast cancer.

  

 Pharmaco-Kinetics :

It is administered as influsion. After infusion it undergoes intensive P450-mediated hepatic metabolism. The clearance of Paclitaxel is saturable and decreases with increasing dose of dose rate.

  

 Contraindication :

Hypersensitivity to Paclitaxel.

  

 Adverse-Effects :

Bone marrow depression, hypersensitivity reactions, myalgia, chest pain, bradycardia, a stocking-glove sensory neuropathy, mucositis, nausea, vomiting, diarrhoea, alopecia. Altered liver function tests.

  

 Special Precaution :

Safety and efficacy in children has not been established. Monitor haematological functions. The drug should be administered under supervision of a physician experienced in use of cancer chemotherapy.

  

 Interactions :

Cisplatin

:

Given after cisplatin leads to profound myelosuppression.

  

 Dosage :

Adult

:

Adults : 175mg per square metre by I.V. inf. over 3 hours. Repeat every 3 weeks. Pretreat with corticosteroids, antihistaminics & H2 - antagonists.

Children

:

Not recommended.

  

 Duration of action :

Following 1, 3, 6 & 24 hours infusion at dosing levels of 15 - 275mg / m2, mean terminal half-life ranges from 51.1 - 52.7 hours.

  

 Strength & Packing :

  30mg /   5ml  Injection,  
100mg / 17ml  Injection  (vial).

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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