Lignocaine   -   Local Anaesthetic  /  Antiarrhythmic  (class 1b)

  

 Action :

It is a local anaesthetic which stabilises the neuronal membrane and inhibits the ion movements which are necessary for conduction of impulses. In the heart lignocaine reduces phase 4 depolarisation, decreases automaticity. Duration of action potential and effective refactory period is reduced.

  

 Indication :

Infiltration anaesthesia, surface application, epidural anaesthesia, spinal anaesthesia, intravenous regional anaesthesia, nerve block. Topically used for pain caused by haemorrhoids, fissure, insect bite, minor burns. For rectal, vaginal and otological examination, cystoscopy, cathe-terization, urethral operations, endotracheal intubation.

  

 Contraindication :

Hypersensitivity, conduction disturbances, AV block.

  

 Adverse-Effects :

Convulsion, tremor, dizziness, blurred vision, nervousness, nausea and respiratory arrest. Cardiovascular collapse and cardiac arrest. Symptoms may occur quickly, without warning.

  

 Special Precaution :

Resuscitation facilities should be available when local anaesthesia is being given. Bradycardia. Hepatic and renal dysfunction. 

  

 Interactions :

Propranolol

:

Increased lidocaine levels resulting in toxicity.

Cimetidine

:

Decreased lidocaine clearance with possible toxicity.

Procainamide

:

Additive cardiodepressant action may occur with potential for conduction abnormalities.

Tocainide

:

Increased incidence of adverse reactions.

Adrenaline

:

Reduces the absorption of lidocaine.

  

 Dosage :

Adults & Children : Dose depends on clinical condition, age, weight, height, site and purpose for which it is used.

  

 Strength & Packing :

1% - 30ml  Injection,  
2% - 30ml  (20mg / ml), Injection.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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