L-Asparginase  -   Antineoplastic 

  
L-Asparginase (Leucoginase) Injection - an Anti-neoplastic / Oncologyl drug.

  

 Action :

Rapidly depletes asparagines from malignant cells which depend on exogenous sources for survival. Normal cells can synthesize asparagines and are affected less. L-Asparaginase induces remission in some patients with acute lymphocytic leukaemia.

  

 Indication :

Malignant lyphoma, acute leukaemia.

  

 Pharmaco-Kinetics :

It is given by parenteral route.

  

 Contraindication :

Anaphylactic reaction to L-asparaginase, history of pancreatitis or if pancreatitis is present.

  

 Adverse-Effects :

Nausea, vomiting, headache, fever, abdominal pain, hyperglycaemia leading to coma, hypersensitivity, renal damage, coagulation defects, thrombosis, CNS depression or hyperexcitability, acute haemorrhagic pancreatitis.

  

 Special Precaution :

Hypersensitivity.

  

 Interactions :

Vincristine and prednisone

:

Associated with increased toxicity.

Methotrexate

:

Effect on malignant cells diminished or abolished as long as plasma asparginase levels are suppressed.

Cytarabine

:

Synergistic effect.

Lab tests

:

Thyroid function tests : Interferes with its interpretation.

  

 Dosage :

Adults

:

50 - 200 KU / Kg / day or alternate days by I.V. infusion for 28 days.

  

 Duration of action :

Plasma half-life 39 - 49 hours.

  

 Strength & Packing :

10,000 KU Injection.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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