Gentamycin  -  Aminoglycoside antimicrobial

  
Gentamycin Injection - Aminoglycoside antimicrobial, Antibiotic drug.

  

 Action :

Active against a wide range of aerobic Gram-negative and some Gram-positive organisms including E.coli, Enterobacter, Klebsiella, Proteus, Providentia Pseudomonas, Campylobacter, Citrobacter, Serratia, Staph. aureus, Staph. epidermidis and listeria monocytogenes.

  

 Indication :

Serious gentamicisensitive infections. Valuable in critically ill patients, with impaired host defence. Pseu-domonas or Proteus infections; burns, urinary tract infections, lung abscesses, Osteomyelitis, middle ear infection, septicaemia, Meningitis caused by gram negative bacilli. Bacteraemia, peritonitis in skin and soft tissue infections, post-operative infection.

  

 Pharmaco-Kinetics :

Following parenteral administration, it defuses mainly into extracellular fluids. Penetration into CSF is poor.

  

 Contraindication :

Renal failure, hypersensitivity.

  

 Adverse-Effects :

Ototoxicity (incidence is related to dose and duration of therapy), nephrotoxicity, hypersensitivity reactions, skin itching, headache, neuromuscular junction blockade, anorexia, nausea, vomiting, superinfection, photosensitivity, drowsiness, weakness, thrombocytopenia, agranulocytosis.

  

 Special Precaution :

Gentamycin dose is to be given on body weight basis and according to renal function.

  

 Interactions :

Amphotericin B, Cisplatin, Cephalosporin, Vancomycin, Methoxyflurane, Frusemide, Bumetanide

:

Increasednephrotoxicity.

Anaesthetics, Neuromuscular blocking agents (Tubocurarine)

:

 Risk of neuromuscular blockade and respiratory paralysis.

Pencillin, Cephalosprins, Carbenicillin, Ticarcillin

:

Exert antibiotic synergism, especially useful in Pseudomonas infections.

Loop diuretics

:

Concurrent use of these agents may increase the risk of respiratory paralysis and renal dysfunction.

Lab Tests

:

Aminoglycoside serum levels : Guard against in vitro inactivation of aminoglycosides by B-lactum antibiotics in patients on combination therapy.

  

 Dosage :

Adults : 3-5mg / kg body-weight  I.M. daily in divided doses 8 hourly for 7-10 days.

  

 Duration of action :

8-12 hours.  

    

 Strength & Packing :

 

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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