5 - Fluorouracil   -   Antineoplastic / Antimetabolite

  
Manufacturers of 5-Fluorouracil injection, an antimetabolite drug, used as an adjuvant to radiotherapy, surgery, carcinoma of urinary bladder, pancreas, colon

  

 Action :

5-FU interferes with the synthesis of DNA and to a lesser extent that of RNA by blocking the methylation reaction of deoxyuridylic acid to thymidylic acid. This results  in unbalanced growth and that of the cells. The effect of 5 FU is more on rapidly growing cells which take up this drug at a more rapid rate.

  

 Indication :

Used as an adjuvant to radiotherapy, surgery and in combination with other drugs : Maligant neoplasms of breast, G.I.Tract and carcinoma of pancreas. Carcinoma of urinary bladder, hepatoma, carcinoma of colon, topical treatment of premalignant keratosis of skin and multiple superficial basal cell carcinomas.

  

 Pharmaco-Kinetics :

It is administered parenterally because absorption after oral intale is unpredictable and incomplete. It is metabolised in hiver intestinal mucosa and other tissues.

  

 Contraindication :

Serious infection, depressed bone marrow function.

  

 Adverse-Effects :

Nausea, vomiting, diarrhoea, alopecia, conjunctivitis, bone marrow depression, angina pectoris, cardiac arrhythmias, oral and G.I. ulcers, hyperpigmentation. Chest pain, breathlessness.

  

 Special Precaution :

Anaemia, leucopenia, skin pigmentation, eruption. Patient should be hospitalised during 1st course of treatment. Hepatic or renal impairment, hypersensitivity.

  

 Interactions :

Cimetidine

:

Increased plasma fluorouracil concentration.

Other Bone marrow depressants, Immunosuppressive agents, irradiation

:

Additive adverse effects.

Leucovorin calcium

:

Toxicity of fluorouracil enhanced.

Metronidazole

:

Enhanced toxicity.

Lab tests

:

Elevation in alkaline phosphates, serum transaminase, serum bilirubin and lactic dehydrogenase may occur.

  

 Dosage :

Adults

:

12mg / kg body weight once daily for 4 successive days I.V.

Max. daily dose : 800mg. If no toxicity give 6mg / kg on days 6,8,10,12, discontinue day 12.

Maintain dose : 10-15mg / kg per week, Max dose 1g / week.

  

 Duration of action :

Terminal elimination half-life 20 hours.  

    

 Strength & Packing :

250mg /   5ml  Injection,  
500mg / 10ml  Injection,  (amps / vials).

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.