Etoposide   -  Antineoplastic  /  Podophyllum derivative

  
Manufacturers of Etoposide injection, an anti neoplastic - oncology medicine, used in treatment of cancer, testicular tumors, hodgkins,

  

 Action :

The predominant effect of etoposide is inhibition of DNA synthesis resulting in arrest of cell cycle. At low doses etoposide inhibits cells from entering cell cycle. At high doses cells entering mitosis are lysed.

  

 Indication :

Small cell lung cancer. Acute monocytic and myelomonocytic leukaemias. Hodgkin's disease. Non-Hodgkins lymphoma. testicular tumours.

  

 Pharmaco-Kinetics :

After oral administration about 50% drug is absorbed.

  

 Contraindication :

History of previous hypersensitivity. Severe bone marrow failure not due to malignant disease, severe hepatic dysfunction.

  

 Adverse-Effects :

Nausea, vomiting, diarrhoea, allergic reactions, fever, hypotension, bone marrow depression, peripheral neuropathy. Jaundice, bronchospasm.

  

 Special Precaution :

Extravasation, infection, children, adequate contraception. Monitor hepatic, renal and haematological function.

  

 Interactions :

Warfarin : Prolongation of prothrombin time may occur.
Other cytotoxic drugs synergism.

  

 Dosage :

Adults

:

Inj.

:

50-100mg/m2/daily for 5 days (infuse over 30-60 mins.); then 3-4 weeks treatment free; small cell lung cancer 35mg/m2/day for 4 days.

Oral

:

100-200/m2/daily on days 1 to 5l then 3-4 weeks treatment free; take on empty stomach.

Children

:

Not recommended.

     

 Duration of action :

Terminal half-life 3-19 hours.

  

 Strength & Packing :

100mg / 5ml  Injection (per vial).

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

Disclaimer : This guide is provided for information purposes only, and for use of a registered medical practitioner or a hospital or a laboratory only. The authors, webmaster, or respective references / links are no way responsible for the content of the information. Although a concerted effort has been made to ensure the validity of the information contained in this document, we give no assurance for the accuracy of the information in this documents.