Dobutamine  HCl  -  Inotropic sympathomimetic / Cardiovascular  drug

  
Manufacturers of Dobutamine Hydrochloride injection, a cardiovascular drug, used in acute heart failure, cardiogenic shock, cardiac surgery,

  

 Action :

It is a direct acting inotropic agent whose primary action results from stimulation of the beta-1 receptors of the heart, while producing relatively mild chronotropic effects. In patients with depressed cardiac function, dobutamine increases the stroke volume, and cardiac output without marked increase in heart rate. Systemic vascular resistance is usually reduced with dobutamine. Rarely, however, minimum vasoconstriction has been observed.

  

 Indication :

Acute heart failure in acute myocardial infarction, cardiogenic shock, following cardias surgery, septic shock. Acute decompensation of chronic CHF, pharmacological stress testing.

    

 Contraindication :

Idiopathic hypertrophic subaortic stenosis.

  

 Adverse-Effects :

Increased heart rate, blood pressure and ventricular ectopic activity. Hypotension, phlebitis, nausea, headache, nonspecific chest pain, palpitations and shortness of breath.

  

 Special Precaution :

Patients with a trial fibrillation are at risk of developing rapid  ventricular response. Dobutamine may precipitate or exacerbate ventricular ectopic activity. During administration of dobutamine solution, ECG and blood pressure should be continuously monitored. Hypovolemia should be corrected with suitable volume expanders before treatment with dobutamine may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Usually reduction of dosage promptly reverses these effects. In patients who become tolerant to dobutamine while receiving continuous infusions, switching to other drug for several days may allow dobutamine to be reinstituted.

  

 Interactions :

Bretylium

:

Potentiates its action resulting in arrhythmias.

Halogenated hydrocarbon anaesthetics

:

 Risk of serious arrhythmias.

Oxytocic drugs

:

May cause persistent hypertension.

TCAs

:

Use with caution since efficacy of vasopressor enhanced.
Phentolamine & Prazosin : Antagonistic action.
Nitroprusside : Additive effect.

   

 Dosage :

Adults :  

  

 Duration of action :

Half-life 2 mins. 

    

 Strength & Packing :

  

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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