Diclofenac   -   Anti-Inflammatory Drugs

  
Manufacturers of Diclofenc Injection, a non-steroidal antiinfammatory drug

  

 Action :

Diclofenac is an inhibitor of cyclooxygenase. It also appreas to reduce intracellular concentrations of free arachidonate in leukocytes. Its potency is greater than indomethacin, naproxen, etc.

  

 Indication :

Rheumatoid arthritis, ostearthritis, low back pain, ankylosing spondylitis, gout. Acute musculoskeletal disorders, periarthritis (Frozen shoulder) tendinitis, tenosynovitis, bursitis, sprains and dislocations. Painful post-operative conditions. Pain following dental surgery. Painful inflammatory conditions in gynaecology.

  

 Pharmaco-Kinetics :

After oral administration it is rapidly and completely absorbed. It shows substantial first pass effect and is highly protein bound. It is metabolised, excreted in urine and bile.

  

 Contraindication :

GI bleeding, active peptic ulcer, NSAID induced allergic asthma.

  

 Adverse-Effects :

Nausea, vomiting, epigastric discomfort, skin rash, peptic ulcer, fluid retention, oedema, impairment of hepatic function rarely.

  

 Special Precaution :

Impairment of hepatic, renal or cardiac function. Children, blood coagulation disorders. Recent proctitis. GI disorders. Preparations of Diclofenac with paracetamol are available. 

  

 Interactions :

Lithium & Digoxin

:

Blood levels of lithium and digoxin increased leading to enhanced efficacy and possible toxicity.

Diuretics

:

Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.

Methotrexate

:

Toxicity enhanced.

Salicylates

:

Efficacy of salicylates reduced.

Cyclosporine

:

Increases nephrotoxicity of both agents.

Hydantoins

:

Increases serum levels resulting in toxicity.

  

 Dosage :

Adults

:

100 - 150mg daily in 2-3 divided doses.

Maintenance therapy

:

50-100mg in divided doses

Children

:

Not recommended.

  

 Duration of action :

Upto 12 hours.

  

 Strength & Packing :

25mg / ml,  3ml  Injection, (10 ampoules per box). 

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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