Chlorambucil   -   Alkylating Antineoplastic

  

 Action :

Chlorambucil arrests cell cycle at the G2 (premitotic) stage. It crosses cross-linking of the cellular DNA strands. DNA breaks down and cell dies.

  

 Indication :

Chronic Lymphocytic Leukaemia (drug of choice), Primary (Waldenstrom's) macroglobulinaemia, advanced ovarian adeno carcinoma, breast cancer, certain forms of non-Hodgkin's Lymphoma, Hodgkin's disease.

  

 Pharmaco-Kinetics :

After oral administration it shows reliable and adequate absorption. It is almost completely metabolised.

  

 Contraindication :

Hypersensitivity.

  

 Adverse-Effects :

Nausea, vomiting, epigastric discomfort, pulmonary fibrosis, dermatitis, seizures, hepatotoxicity, amenorrhoea, azoospermia, bone marrow depression. Peripheral neuropathy.

  

 Special Precaution :

Carcinogenic potential, altered fertility, haematological monitoring, extravasation, hyperuricaemia, porphyria.

  

 Interactions :

Other Myelosuppressive Agents

:

Efficacy of these enhanced.

Phenlebutazone & Warfarin

:

Potentiate the efficacy of Chlorambucil.

  

 Dosage :

0.1 - 0.2mg / kg body weight daily for 4-8 weeks. For chronic lymphocytic leukaemia - 0.4mg / kg bi weekly or monthly. Increased by 0.1mg / kg till lymphocytosis is controlled.

Maintenance dose : 0.1mg/kg per day or may be low dose of 0.03 mg/kg.

Children : Not recommended.

  

 Onset of action :

15 - 30 mins.

 

 Duration of action :

Terminal elimination half-life 2 - 2.5 hours.  

    

 Strength & Packing :

2mg tablet,  
5mg tablet,  25 tablets per bottle.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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