Busulphan   -   Alkylating  /  Antileukemia

  
Manufactures Busulphan tablets, an Alkylating / Anti-leukemia drug

  

 Action :

Busulphan is an alkylating agent. It depresses bone marrow function, reduces total granulocyte mass and improves the clinical state.

  

 Indication :

Chronic myelogenous leukaemia, polycythaemia vera, essential thrombocythaemia, myelofibrosis.

  

 Pharmaco-Kinetics :

After oral administration it is well absorbed. Almost all the drug is excreted via urine as Methanesulfonic acid.

  

 Contraindication :

Hypersensitivity.

  

 Adverse-Effects :

Nausea, vomiting, pulmonary fibrosis, alopecia, generalized skin pigmentation, azoospermia, cataract, gynaecomastia, ovarian failure, leukaemia, hyperuricaemia.

  

 Special Precaution :

Drug may be leukaemogenic and carcinogenic. Patient should be hospitalised during induction therapy. Haematological monitoring, hyperuricaemia.

  

 Interactions :

Immunisation with live viruses

:

Life threatening infection.

Theoguanine

:

Nodular regenerative hyperplasia leading to oesophageal varices and abnormal liver function tests.

  

 Dosage :

Dose and duration dependent on condition. For remission 4 - 8mg / day. 1 - 3mg / day as maintenance dose.

  

 Onset of action :

Decrease in leukocyte count occurs after 10-15 days.

  

 Duration of action :

Decrease in leukocyte count may continue for 1 month after withdrawal of the drug.

    

 Strength & Packing :

2mg tablet,   100 tablets per bottle.

  
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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Shree  Ganesh  Pharmaceuticals
Mumbai - India.
  
Web site :  http://www.sgpharma.com             E-mail  :  exports@sgpharma.com

  

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