Amoxycillin  -  Amenopenicillin  Antimicrobial

  

 Action :

Amoxycillin is bactericidal by virtue of its ability to inhibit synthesis of the bacterial call wall. The benzyl ring in the side chain extends the antimicrobial action to Gram negative bacteria. Bacteria susceptible to amoxycillin include alpha and beta haemolytic streptococci, strep pneumoniae, strep faecalis, bacillus anthracis, clostridium spp. Except C. difficile, some non-betalactamase staphylococci, B. pertussis, Branhamella, Neisseriae, Haemophilus, E.coli, Proteus, Salmonella, Shigella, Treponema, Betalactamase producing organisms, Pseudomonas, most strains Mycobacteria and viruses are not susceptible to amoxycillin. Among fungi actinomyces are sensitive.

  

 Indication :

Respiratory, genitourinary, skin & soft tissue, ENT infections caused by pneumococci, streptococci, staphylococci, H. influenzae, E. coli & other susceptible organisms. Chlamydia trachomatis in pregnancy. Meningitis due to susceptible strains of gram-ve micro organisms. Enteric fever, Gonococcal urethritis, bacteraemia, septicaemia.

  

 Pharmaco-Kinetics :

Food does not interfere with its absorption. Its absorption after oral administration is complete hence less incidence of diarrhoea. It is eliminated largely via urine as unchanged drug.

  

 Contraindication :

Hypersensitivity to penicillin.

  

 Adverse-Effects :

Nausea, epigastric distress, diarrhoea, skin rash especially in patients with monouncleosis, urticaria and serum sickness, thrombocytopenic purpura, leucopenia and eosinophilla. Pseudomembranous colitis, superinfection.

  

 Special Precaution :

In chronic theraphy periodic assessment of renal and haemopoeitic function should be made.

  

 Interactions :

Oral contraceptives

:

Efficacy reduced, may cause breakthrough bleeding or pregnancy.

Erythromycin, Tetracycline

:

Reduce efficacy.

  

 Dosage :

Adults 250-500mg thrice daily. 
Gonorrhoea  : Single dose of 3 g. 
Enteric fever : 2-4 g daily in divided doses for 14-21 days.

  

 Duration of action :

8 hours.  

    

 Strength & Packing :

 

  
   
*  for the use of a registered Medical practitioner or a Hospital or a Laboratory only.

  

  

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